Team members from the Institute of Medical Physics and Radiation Protection (IMPS) within The Technische Hochschule Mittelhessen (THM), a BoneOscopy’s project partner, presented their research results related to Monte Carlo simulations at three different conferences. Two presentations out of the six posters and five talks were directly funded by BoneOscopy:

1. The 2025 Congress of the European Society for Radiotherapy and Oncology (ESTRO 2025) from 2-6 May in Vienna, Austria
   • Poster titled “A novel approach to enable dose rate simulations within the chemical phase of Geant4-DNA using the step-by-step method”
   • Poster titled “Validating Radical Yield Predictions in Monte Carlo Simulations of Water Radiolysis Using Fricke Solution and Sodium Nitrate Scavenging”
   • Poster titled “Development of an enhanced Fricke-Based Chemical Dosimeter Utilizing Sorbitol and Xylenol Orange for Signal Amplification”
   • Poster titled “Chemistry simulations following radiolysis with consideration of interaction potentials”
   • Talk on “Experimental validation of Monte Carlo simulated beam quality correction factors kQ for monoenergetic carbon-ion beams”
2. The 63^rd Annual Conference of the Particle Therapy Cooperative Group (PTCOG 63) from 2-7 June Buenos Aires, Argentina
   • Talk on “Dosimetric study of lung modulation and motion effects in carbon ion therapy for lung cancer”
3. The 56^th Annual Meeting of the German Society for Medical Physics (DGMP) from 24-27 September in Berlin, Germany
   • Poster titled “Einfluss der Definition der Dosisleistung auf das Ansprechvermögen chemischer Dosimeter”
   • Poster titled “Monte Carlo basierte Untersuchung der Auswirkung der Zellgeometrie auf die DNA-Schadensausbeute bei Bestrahlung mit ionisierenden Strahlungsarten”
   • Talk on “Entwicklung eines Cluster-Algorithmus zur automatisierten Berechnung der lokalen Lungenmodulationsstärke”
   • Talk on “Optimierung eines chemischen Dosimeters auf FRICKE-Basis”
   • Talk on “Entwicklung eines Modells zur Berücksichtigung intermolekularer Wechselwirkungen in Monte-Carlo-Simulationen der chemischen Phase”

IMPS is known for its focus on applications and research in radiation and particle therapy, imaging, and radiation protection. The Particle Therapy Working Group within IMPS has extensive expertise in Monte Carlo simulations on both macroscopic and microscopic scales. Through a strong collaboration with the University Hospital Giessen-Marburg and the Marburg Ion-Beam Therapy Center, they conduct benchmark experiments to refine and validate Monte Carlo models. Recent studies have focused on optimising the modeling of the chemical phase using FRICKE dosimeters, with particular emphasis on applications involving FLASH dose rates. Within BoneOscopy, Monte Carlo simulations will be conducted to analyse the expected spectrum of prompt gamma photons emitted when bone tissue with varying calcium concentrations is irradiated with particles. These simulations will serve as the basis for training a neural network designed to reconstruct the applied dose and determine the calcium concentration in the bone tissue from the measured prompt gamma spectrum.