The Technische Hochschule Mittelhessen (THM) is a University of Applied Sciences with approximately 16,000 students. The university specialises in programs oriented towards the natural sciences, engineering, and technology. With campuses in Giessen, Friedberg, and Wetzlar, THM offers a diverse portfolio of 80 study programs.

Within THM, the Institute of Medical Physics and Radiation Protection (IMPS) focuses on applications and research in radiation and particle therapy, imaging, and radiation protection. The Particle Therapy Working Group within IMPS has extensive expertise in Monte Carlo simulations on both macroscopic and microscopic scales. The group contributed to the EMPIR project, “kQ Factors in Modern External Beam Radiotherapy Applications to Update IAEA TRS-398,” generating values for clinical proton beam kQ factors. Their work has significantly advanced dosimetry for proton and carbon-ion beams, including studies on the effects of magnetic fields.

Through a strong collaboration with the University Hospital Giessen-Marburg and the Marburg Ion-Beam Therapy Center, the working group conducts benchmark experiments to refine and validate Monte Carlo models. Recent studies have focused on optimising the modeling of the chemical phase using FRICKE dosimeters, with particular emphasis on applications involving FLASH dose rates.

As part of the BoneOscopy project, THM will oversee the installation of a prototype detector system at the Marburg Ion-Beam Therapy Center. Following installation, the prototype will undergo commissioning and validation against predictive modeling.

To support this effort, Monte Carlo simulations will be conducted to analyse the expected spectrum of prompt gamma photons emitted when bone tissue with varying calcium concentrations is irradiated with particles. These simulations will serve as the basis for training a neural network designed to reconstruct the applied dose and determine the calcium concentration in the bone tissue from the measured prompt gamma spectrum.